Cherokee is loaded with huge Stripers and Hybrids and fall is a great time of year to catch them using conventional bass tackle. Focus on looking at main lake points and islands around creek mouths. I have had the best luck riding and looking for schooling fish gorging on shad around the dam area. Mornings and evenings are best, some anglers even sit still on the main lake looking for schoolers, kind of like hunting. Grab you a topwater and go find them. Once you found them, keep you bait wet and have fun!